New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases

Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) fo...

Full description

Bibliographic Details
Main Authors:	Jian Lu, Xuyang Shang, Weiguo Zhong, Yuan Xu, Rong Shi, Xin Wang
Format:	Article
Language:	English
Published:	Elsevier 2020-01-01
Series:	Acta Pharmaceutica Sinica B
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383519307701

id	doaj-652512ec050c45aba0c35d0f9089eb0a
record_format	Article
spelling	doaj-652512ec050c45aba0c35d0f9089eb0a2020-11-25T01:52:36ZengElsevierActa Pharmaceutica Sinica B2211-38352020-01-0110191104New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseasesJian Lu0Xuyang Shang1Weiguo Zhong2Yuan Xu3Rong Shi4Xin Wang5Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, ChinaChangning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, ChinaChangning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, ChinaShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, ChinaDepartment of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaChangning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China; Corresponding author. Tel.: +86 21 24206564; fax: +86 21 54344922.Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) for CYP1A genes may affect the metabolic ability of endogenous substances, leading to some physiological or pathological changes in humans. This review first summarizes the metabolism of endogenous substances by CYP1A, and then introduces the research progress of CYP1A SNPs, especially the research related to human diseases. Finally, the relationship between SNPs and diseases is discussed. In addition, potential animal models for CYP1A gene editing are summarized. In conclusion, CYP1A plays an important role in maintaining the health in the body. Key words: CYP1A, Endogenous substances, Xenobiotics, SNPs, Metabolism and diseasehttp://www.sciencedirect.com/science/article/pii/S2211383519307701
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jian Lu Xuyang Shang Weiguo Zhong Yuan Xu Rong Shi Xin Wang
spellingShingle	Jian Lu Xuyang Shang Weiguo Zhong Yuan Xu Rong Shi Xin Wang New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases Acta Pharmaceutica Sinica B
author_facet	Jian Lu Xuyang Shang Weiguo Zhong Yuan Xu Rong Shi Xin Wang
author_sort	Jian Lu
title	New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases
title_short	New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases
title_full	New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases
title_fullStr	New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases
title_full_unstemmed	New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases
title_sort	new insights of cyp1a in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases
publisher	Elsevier
series	Acta Pharmaceutica Sinica B
issn	2211-3835
publishDate	2020-01-01
description	Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) for CYP1A genes may affect the metabolic ability of endogenous substances, leading to some physiological or pathological changes in humans. This review first summarizes the metabolism of endogenous substances by CYP1A, and then introduces the research progress of CYP1A SNPs, especially the research related to human diseases. Finally, the relationship between SNPs and diseases is discussed. In addition, potential animal models for CYP1A gene editing are summarized. In conclusion, CYP1A plays an important role in maintaining the health in the body. Key words: CYP1A, Endogenous substances, Xenobiotics, SNPs, Metabolism and disease
url	http://www.sciencedirect.com/science/article/pii/S2211383519307701
work_keys_str_mv	AT jianlu newinsightsofcyp1ainendogenousmetabolismafocusonsinglenucleotidepolymorphismsanddiseases AT xuyangshang newinsightsofcyp1ainendogenousmetabolismafocusonsinglenucleotidepolymorphismsanddiseases AT weiguozhong newinsightsofcyp1ainendogenousmetabolismafocusonsinglenucleotidepolymorphismsanddiseases AT yuanxu newinsightsofcyp1ainendogenousmetabolismafocusonsinglenucleotidepolymorphismsanddiseases AT rongshi newinsightsofcyp1ainendogenousmetabolismafocusonsinglenucleotidepolymorphismsanddiseases AT xinwang newinsightsofcyp1ainendogenousmetabolismafocusonsinglenucleotidepolymorphismsanddiseases
_version_	1724994205535698944

New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases

Similar Items