Intracellular Glutathione Depletion by Oridonin Leads to Apoptosis in Hepatic Stellate Cells

Intracellular Glutathione Depletion by Oridonin Leads to Apoptosis in Hepatic Stellate Cells

Proliferation of hepatic stellate cells (HSCs) plays a key role in the pathogenesis of liver fibrosis. Induction of HSC apoptosis by natural products is considered an effective strategy for treating liver fibrosis. Herein, the apoptotic effects of 7,20-epoxy-ent-kaurane (oridonin), a diterpenoid iso...

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Bibliographic Details
Main Authors: Liang-Mou Kuo, Chan-Yen Kuo, Chen-Yu Lin, Min-Fa Hung, Jiann-Jong Shen, Tsong-Long Hwang
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Molecules
Subjects:
apoptosis
glutathione
hepatic stellate cells
oridonin
reactive oxygen species
Online Access:http://www.mdpi.com/1420-3049/19/3/3327

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http://www.mdpi.com/1420-3049/19/3/3327

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