Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation

Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation

Microtubules (MTs) are dynamic structures that are fundamental for cell morphogenesis and motility. MT-associated motors work efficiently to perform their functions. Unlike other motile kinesins, KIF2 catalytically depolymerizes MTs from the peeled protofilament end during ATP hydrolysis. However, t...

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Bibliographic Details
Main Authors: Tadayuki Ogawa, Shinya Saijo, Nobutaka Shimizu, Xuguang Jiang, Nobutaka Hirokawa
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
microtubule
catalytic depolymerization
kinesin-13
KIF2
MCAK
ATP hydrolysis
molecular motor
microtubule destabilizer
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471731207X

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http://www.sciencedirect.com/science/article/pii/S221112471731207X

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