Trypanosoma brucei Lipophosphoglycan Induces the Formation of Neutrophil Extracellular Traps and Reactive Oxygen Species Burst via Toll-Like Receptor 2, Toll-Like Receptor 4, and c-Jun N-Terminal Kinase Activation

Trypanosoma brucei Lipophosphoglycan Induces the Formation of Neutrophil Extracellular Traps and Reactive Oxygen Species Burst via Toll-Like Receptor 2, Toll-Like Receptor 4, and c-Jun N-Terminal Kinase Activation

Trypanosoma brucei brucei is the causative agent of African animal trypanosomosis, which mainly parasitizes the blood of the host. Lipophosphoglycan (LPG), a polymer anchored to the surface of the parasites, activates the host immune response. In this study, we revealed that T. brucei LPG stimulated...

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Bibliographic Details
Main Authors: Kai Zhang, Ning Jiang, Xiaoyu Sang, Ying Feng, Ran Chen, Qijun Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Microbiology
Subjects:
Trypanosoma brucei
neutrophil
lipophosphoglycan
neutrophil extracellular trap
c-Jun N-terminal kinase
toll-like receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.713531/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.713531/full

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