Rapamycin Loaded Solid Lipid Nanoparticles as a New Tool to Deliver mTOR Inhibitors: Formulation and in Vitro Characterization

Rapamycin Loaded Solid Lipid Nanoparticles as a New Tool to Deliver mTOR Inhibitors: Formulation and in Vitro Characterization

Recently, the use of mammalian target of rapamycin (mTOR) inhibitors, in particular rapamycin (Rp), has been suggested to improve the treatment of neurodegenerative diseases. However, as Rp is a strong immunosuppressant, specific delivery to the brain has been postulated to avoid systemic exposure....

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Bibliographic Details
Main Authors: Alice Polchi, Alessandro Magini, Jarosław Mazuryk, Brunella Tancini, Jacek Gapiński, Adam Patkowski, Stefano Giovagnoli, Carla Emiliani
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Nanomaterials
Subjects:
rapamycin
solid lipid nanoparticles
drug delivery
formulation
SH-SY5Y neuroblastoma cells
Online Access:http://www.mdpi.com/2079-4991/6/5/87

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http://www.mdpi.com/2079-4991/6/5/87

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