Distinct Activities of Gli1 and Gli2 in the Absence of Ift88 and the Primary Cilia
The primary cilia play essential roles in Hh-dependent Gli2 activation and Gli3 proteolytic processing in mammals. However, the roles of the cilia in Gli1 activation remain unresolved due to the loss of <i>Gli1</i> transcription in cilia mutant embryos, and the inability to address this...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-02-01
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| Series: | Journal of Developmental Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2221-3759/7/1/5 |