Oxidative Stress, Kinase Activation, and Inflammatory Pathways Involved in Effects on Smooth Muscle Cells During Pulmonary Artery Hypertension Under Hypobaric Hypoxia Exposure

Oxidative Stress, Kinase Activation, and Inflammatory Pathways Involved in Effects on Smooth Muscle Cells During Pulmonary Artery Hypertension Under Hypobaric Hypoxia Exposure

High-altitude exposure results in hypobaric hypoxia, which affects organisms by activating several mechanisms at the physiological, cellular, and molecular levels and triggering the development of several pathologies. One such pathology is high-altitude pulmonary hypertension (HAPH), which is initia...

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Bibliographic Details
Main Authors: Patricia Siques, Eduardo Pena, Julio Brito, Samia El Alam
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
hypobaric hypoxia
pulmonary artery smooth muscle cell
oxidative stress
kinases
inflammation
high altitude
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.690341/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.690341/full

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