Functional domains of SP110 that modulate its transcriptional regulatory function and cellular translocation

Functional domains of SP110 that modulate its transcriptional regulatory function and cellular translocation

Abstract Background SP110, an interferon-induced nuclear protein, belongs to the SP100/SP140 protein family. Very recently, we showed that SP110b, an SP110 isoform, controls host innate immunity to Mycobacterium tuberculosis infection by regulating nuclear factor-κB (NF-κB) activity. However, it rem...

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Bibliographic Details
Main Authors: Jia-Shiun Leu, So-Yi Chang, Chia-Yu Mu, Mei-Ling Chen, Bo-Shiun Yan
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Biomedical Science
Subjects:
Functional domain
Transcriptional regulation
Cellular translocation
Nucleolar localization signal
Nuclear localization signal
Online Access:http://link.springer.com/article/10.1186/s12929-018-0434-4

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http://link.springer.com/article/10.1186/s12929-018-0434-4

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