VCP Is an integral component of a novel feedback mechanism that controls intracellular localization of catalase and H2O2 Levels.

Catalase is a key antioxidant enzyme that catalyzes the decomposition of hydrogen peroxide (H2O2) to water and oxygen, and it appears to shuttle between the cytoplasm and peroxisome via unknown mechanisms. Valosin-containing protein (VCP) belongs to the AAA class of ATPases and is involved in divers...

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Bibliographic Details
Main Authors: Katsuhiro Murakami, Yuzuru Ichinohe, Masaaki Koike, Norio Sasaoka, Shun-ichiro Iemura, Tohru Natsume, Akira Kakizuka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3573100?pdf=render