Inducible Pluripotent Stem Cells to Model and Treat Inherited Degenerative Diseases of the Outer Retina: 3D-Organoids Limitations and Bioengineering Solutions

Inducible Pluripotent Stem Cells to Model and Treat Inherited Degenerative Diseases of the Outer Retina: 3D-Organoids Limitations and Bioengineering Solutions

Inherited retinal degenerations (IRD) affecting either photoreceptors or pigment epithelial cells cause progressive visual loss and severe disability, up to complete blindness. Retinal organoids (ROs) technologies opened up the development of human inducible pluripotent stem cells (hiPSC) for diseas...

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Bibliographic Details
Main Authors: Massimiliano Andreazzoli, Ivana Barravecchia, Chiara De Cesari, Debora Angeloni, Gian Carlo Demontis
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
iPSC
retinal organoids
inherited retinal degenerations
photoreceptors
disease modeling
transplantation
Online Access:https://www.mdpi.com/2073-4409/10/9/2489

Internet

https://www.mdpi.com/2073-4409/10/9/2489

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