Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice

Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice

Abstract We examined the effect of chronic high fat diet (HFD) on amyloid deposition and cognition of 12-months old APP23 mice, and correlated the phenotype to brain transcriptome and lipidome. HFD significantly increased amyloid plaques and worsened cognitive performance compared to mice on normal...

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Bibliographic Details
Main Authors: Kyong Nyon Nam, Anais Mounier, Cody M. Wolfe, Nicholas F. Fitz, Alexis Y. Carter, Emilie L. Castranio, Hafsa I. Kamboh, Valerie L. Reeves, Jianing Wang, Xianlin Han, Jonathan Schug, Iliya Lefterov, Radosveta Koldamova
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04412-2

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https://doi.org/10.1038/s41598-017-04412-2

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