Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis.

The rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) tuberculosis around the world, including in industrialized nations, poses a great threat to human health and defines a need to develop new, effective and inexpensive anti-tubercular agents. Previously we developed a chemical...

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Bibliographic Details
Main Authors: Sarah L Kinnings, Nina Liu, Nancy Buchmeier, Peter J Tonge, Lei Xie, Philip E Bourne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS Computational Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19578428/pdf/?tool=EBI