Optimization of amino acid replacement costs by mutational pressure in bacterial genomes

Abstract Mutations are considered a spontaneous and random process, which is important component of evolution because it generates genetic variation. On the other hand, mutations are deleterious leading to non-functional genes and energetically costly repairs. Therefore, one can expect that the muta...

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Bibliographic Details
Main Authors: Paweł Błażej, Dorota Mackiewicz, Małgorzata Grabińska, Małgorzata Wnętrzak, Paweł Mackiewicz
Format: Article
Language:English
Published: Nature Publishing Group 2017-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01130-7