Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium

Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium

Oestrogen receptors α (ERα) are expressed in a subset of mammary epithelial cells. Here, the authors identify cells with low-ERα protein levels and show that distinct cell populations have distinct requirements for the AF1 and AF2 domains of the ERα, and ERα acts in a biphasic manner dependent on de...

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Bibliographic Details
Main Authors: Stéphanie Cagnet, Dalya Ataca, George Sflomos, Patrick Aouad, Sonia Schuepbach-Mallepell, Henry Hugues, Andrée Krust, Ayyakkannu Ayyanan, Valentina Scabia, Cathrin Brisken
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07175-0

Internet

https://doi.org/10.1038/s41467-018-07175-0

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