Aldosterone blockade in heart failure

Aldosterone plays a key role in the pathophysiology of heart failure. Angiotensin converting enzyme inhibitors and angiotensin II receptor blockers may not suppress aldosterone production in the long term. This allows aldosterone to exert its effects on myocardial fibrosis and cardiac remodelling, e...

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Bibliographic Details
Main Author: Allan D Struthers
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2004-03-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:http://jra.sagepub.com/content/5/1_suppl/S23.full.pdf