Acidic Microenvironment Regulates the Severity of Hepatic Ischemia/Reperfusion Injury by Modulating the Generation and Function of Tregs via the PI3K-mTOR Pathway

Acidic Microenvironment Regulates the Severity of Hepatic Ischemia/Reperfusion Injury by Modulating the Generation and Function of Tregs via the PI3K-mTOR Pathway

Hepatic ischemia/reperfusion injury (HIRI) is a major cause of liver dysfunction and even liver failure after liver transplantation and hepatectomy. One of the critical mechanisms that lead to HIRI is an acidic microenvironment, which develops due to the accumulation of high acid-like substances suc...

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Bibliographic Details
Main Authors: Xiaojie Gan, Rongsheng Zhang, Jian Gu, Zheng Ju, Xiao Wu, Qi Wang, Hao Peng, Jiannan Qiu, Jinren Zhou, Feng Cheng, Ling Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
acidic microenvironment
Treg
hepatic ischemia/reperfusion injury
immune cells
signaling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02945/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02945/full

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