Simultaneous quantitation of folic acid and 5-methyltetrahydrofolic acid in human plasma by HPLCâMS/MS and its application to a pharmacokinetic study

Simultaneous quantitation of folic acid and 5-methyltetrahydrofolic acid in human plasma by HPLCâMS/MS and its application to a pharmacokinetic study

A sensitive method based on high-performance liquid chromatographyâtandem mass spectrometry (LCâMS/MS) has been developed for the simultaneous determination of folic acid (FA) and its active metabolite, 5-methyltetrahydrofolic acid (5-M-THF), in human plasma. The analytes were extracted from plasma...

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Bibliographic Details
Main Authors:	Xiao-Hong Zheng, Li-Yuan Jiang, Lan-Ting Zhao, Quan-Ying Zhang, Li Ding
Format:	Article
Language:	English
Published:	Elsevier 2015-08-01
Series:	Journal of Pharmaceutical Analysis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2095177915000544

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