Simultaneous quantitation of folic acid and 5-methyltetrahydrofolic acid in human plasma by HPLCâMS/MS and its application to a pharmacokinetic study
A sensitive method based on high-performance liquid chromatographyâtandem mass spectrometry (LCâMS/MS) has been developed for the simultaneous determination of folic acid (FA) and its active metabolite, 5-methyltetrahydrofolic acid (5-M-THF), in human plasma. The analytes were extracted from plasma...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-08-01
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| Series: | Journal of Pharmaceutical Analysis |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177915000544 |