GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease

GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease

Cholinergic interneurons of the striatum are involved reward-related behaviors and have been implicated in Parkinson’s disease. Here the authors report that half of cholinergic neurons co-release acetylcholine and GABA, and study the role of these neurons in a model of Parkinson’s Disease.

Bibliographic Details
Main Authors: N. Lozovaya, S. Eftekhari, R. Cloarec, L. A. Gouty-Colomer, A. Dufour, B. Riffault, M. Billon-Grand, A. Pons-Bennaceur, N. Oumar, N. Burnashev, Y. Ben-Ari, C. Hammond
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03802-y

Internet

https://doi.org/10.1038/s41467-018-03802-y

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