A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRDM9-bound loci do not become recombination hotspots. To explore factors that affect binding and subsequent recombination outcomes, we mapped human PRDM9 binding sites in a transfected human cell line a...

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Bibliographic Details
Main Authors: Nicolas Altemose, Nudrat Noor, Emmanuelle Bitoun, Afidalina Tumian, Michael Imbeault, J Ross Chapman, A Radu Aricescu, Simon R Myers
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
meiosis
recombination
zinc finger protein
transposable elements
PRDM9
KRAB
Online Access:https://elifesciences.org/articles/28383

Internet

https://elifesciences.org/articles/28383

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