Novel Breast Cancer Brain Metastasis Patient-Derived Orthotopic Xenograft Model for Preclinical Studies

Novel Breast Cancer Brain Metastasis Patient-Derived Orthotopic Xenograft Model for Preclinical Studies

The vast majority of mortality in breast cancer results from distant metastasis. Brain metastases occur in as many as 30% of patients with advanced breast cancer, and the 1-year survival rate of these patients is around 20%. Pre-clinical animal models that reliably reflect the biology of breast canc...

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Bibliographic Details
Main Authors: Masanori Oshi, Maiko Okano, Aparna Maiti, Omar M. Rashid, Katsuharu Saito, Koji Kono, Ryusei Matsuyama, Itaru Endo, Kazuaki Takabe
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
brain metastasis
breast cancer
epothilone
gene expression
mouse model
orthotopic implantation
pdx
pre-clinical model
xenograft
Online Access:https://www.mdpi.com/2072-6694/12/2/444

Internet

https://www.mdpi.com/2072-6694/12/2/444

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