FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism

FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism

Insulin signaling represses Forkhead transcription factor FoxO activity, which contributes to organismal metabolism. Here, the authors use proteomics to identify positively regulated insulin signaling targets FoxK1/K2 and demonstrate their role in lipid metabolism and mitochondrial regulation.

Bibliographic Details
Main Authors: Masaji Sakaguchi, Weikang Cai, Chih-Hao Wang, Carly T. Cederquist, Marcos Damasio, Erica P. Homan, Thiago Batista, Alfred K. Ramirez, Manoj K. Gupta, Martin Steger, Nicolai J. Wewer Albrechtsen, Shailendra Kumar Singh, Eiichi Araki, Matthias Mann, Sven Enerbäck, C. Ronald Kahn
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09418-0

Internet

https://doi.org/10.1038/s41467-019-09418-0

Similar Items