Neddylation Regulates Macrophages and Implications for Cancer Therapy

Neddylation Regulates Macrophages and Implications for Cancer Therapy

Tumor-associated macrophages (TAMs) promote cancer progression via stimulating angiogenesis, invasion/metastasis, and suppressing anti-cancer immunity. Targeting TAMs is a potential promising cancer therapeutic strategy. Neddylation adds the ubiquitin-like protein NEDD8 to substrates, and thereby re...

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Bibliographic Details
Main Authors: Yanyu Jiang, Lihui Li, Yan Li, Guangwei Liu, Robert M. Hoffman, Lijun Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
macrophage
neddylation
cytokine
migration
polarization
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.681186/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.681186/full

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