MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer

MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer

Abstract Background Triple-negative breast cancer (TNBC) is a poor prognostic breast cancer with the highest mutations and limited therapeutic choices. Cytokine networking between cancer cells and the tumor microenvironment (TME) maintains the self-renewing subpopulation of breast cancer stem cells...

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Bibliographic Details
Main Authors: Yueh-Shan Weng, Hong-Yu Tseng, Yen-An Chen, Pei-Chun Shen, Aushia Tanzih Al Haq, Li-Mei Chen, Yi-Chung Tung, Hsin-Ling Hsu
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Molecular Cancer
Subjects:
MCT-1/miR-34a/IL-6/IL-6R pathway
EMT
M2 macrophages
Cancer stemness
Online Access:http://link.springer.com/article/10.1186/s12943-019-0988-0

Internet

http://link.springer.com/article/10.1186/s12943-019-0988-0

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