Unveiling Druggable Pockets by Site-Specific Protein Modification: Beyond Antibody-Drug Conjugates

Site-specific modification approaches have been extensively employed in the development of protein-based technologies. In this field, stability and activity integrity are the envisioned features of chemically modified proteins. These methods are especially used in the design of antibody-drug conjuga...

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Bibliographic Details
Main Authors: Dailén G. Martínez, Stefan Hüttelmaier, Jean B. Bertoldo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Chemistry
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2020.586942/full