Therapeutic potential of hyporesponsive CD4+ T cells in autoimmunity

Therapeutic potential of hyporesponsive CD4+ T cells in autoimmunity

The interaction between dendritic cells (DCs) and T cells is crucial on immunity or tolerance induction. In an immature or semi-mature state, DCs induce tolerance through T cell deletion, generation of regulatory T cells and/or induction of T cell anergy. Anergy is defined as an unresponsive state t...

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Bibliographic Details
Main Authors: Jaxaira eMaggi, Carolina eSchäfer, Gabriela eUbilla-Olguín, Diego eCatalan, Katina eSchinnerling, Juan C Aguillon
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Immunology
Subjects:
Autoimmune Diseases
Immunotherapy
regulatory T cells
Tolerogenic dendritic cells
hyporesponsiveness
T cell anergy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00488/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00488/full

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