Activating transcription factor 4 regulates stearate-induced vascular calcification

Activating transcription factor 4 regulates stearate-induced vascular calcification

Previously, we reported that stearate, a saturated fatty acid, promotes osteoblastic differentiation and mineralization of vascular smooth muscle cells (VSMC). In this study, we examined the molecular mechanisms by which stearate promotes vascular calcification. ATF4 is a pivotal transcription facto...

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Bibliographic Details
Main Authors: Masashi Masuda, Tabitha C. Ting, Moshe Levi, Sommer J. Saunders, Shinobu Miyazaki-Anzai, Makoto Miyazaki
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Journal of Lipid Research
Subjects:
stearoyl-CoA desaturase
endoplasmic reticulum
fatty acid/desaturases
fatty acid/metabolism
smooth muscle cells
vascular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520418589

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http://www.sciencedirect.com/science/article/pii/S0022227520418589

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