Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH[S]

Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH[S]

We recently reported that cholesterol crystals form in hepatocyte lipid droplets (LDs) in human and experimental nonalcoholic steatohepatitis. Herein, we assigned WT C57BL/6J mice to a high-fat (15%) diet for 6 months, supplemented with 0%, 0.25%, 0.5%, 0.75%, or 1% dietary cholesterol. Increasing d...

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Bibliographic Details
Main Authors: George N. Ioannou, Savitha Subramanian, Alan Chait, W. Geoffrey Haigh, Matthew M. Yeh, Geoffrey C. Farrell, Sum P. Lee, Christopher Savard
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Journal of Lipid Research
Subjects:
cholesterol crystal
nonalcoholic steatohepatitis
lipotoxicity
fatty liver
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520310002

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http://www.sciencedirect.com/science/article/pii/S0022227520310002

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