Nitric oxide/cGMP pathway signaling actively down-regulates α<sub>4</sub>β<sub>1</sub>-integrin affinity: an unexpected mechanism for inducing cell de-adhesion
<p>Abstract</p> <p>Background</p> <p>Integrin activation in response to inside-out signaling serves as the basis for rapid leukocyte arrest on endothelium, migration, and mobilization of immune cells. Integrin-dependent adhesion is controlled by the conformational state...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-05-01
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| Series: | BMC Immunology |
| Online Access: | http://www.biomedcentral.com/1471-2172/12/28 |