Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer

Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer

Full-length (FL) docking protein-1 (DOK1) is an adapter protein which inhibits growth factor and immune response pathways in normal tissues, but is frequently lost in human cancers. Small DOK1 variants remain in cells of solid tumors and leukemias, albeit, their functions are elusive. To assess the...

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Bibliographic Details
Main Authors: Teresa Friedrich, Michaela Söhn, Tobias Gutting, Klaus-Peter Janssen, Hans-Michael Behrens, Christoph Röcken, Matthias P.A. Ebert, Elke Burgermeister
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:EBioMedicine
Subjects:
Docking protein
DOK
RAS
PPAR
Colorectal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416301864

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http://www.sciencedirect.com/science/article/pii/S2352396416301864

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