Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder

Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder

Allopregnanolone and its equipotent stereoisomer, pregnanolone (together termed ALLO), are neuroactive steroids that positively and allosterically modulate the action of gamma-amino-butyric acid (GABA) at GABAA receptors. Levels of ALLO are reduced in the cerebrospinal fluid of female premenopausal...

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Bibliographic Details
Main Authors: Graziano ePinna, Ann M Rasmusson
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Anxiety Disorders
PTSD
Allopregnanolone
GABAA receptor
selective brain steroidogenic stimulants
5α-reductase type I
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00256/full

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http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00256/full

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