Multidrug Resistance-Associated Protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine Sulfoximine

Multidrug Resistance-Associated Protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine Sulfoximine

<p>Abstract</p> <p>Background</p> <p>Multidrug resistance mediated by the multidrug resistance-associated protein 1 (MRP1) decreases cellular drug accumulation. The exact mechanism of MRP1 involved multidrug resistance has not been clarified yet, though glutathione (GSH...

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Bibliographic Details
Main Authors: Savas Burhan, Akca Hakan, Akan Selma, Akan Ilhan, Ozben Tomris
Format: Article
Language:English
Published: BMC 2005-07-01
Series:Cancer Cell International
Subjects:
MRP1
vincristine
HEK293
N-acetylcysteine
BSO
GSH
Online Access:http://www.cancerci.com/content/5/1/22

Internet

http://www.cancerci.com/content/5/1/22

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