Early-life DNA methylation profiles are indicative of age-related transcriptome changes

Early-life DNA methylation profiles are indicative of age-related transcriptome changes

Abstract Background Alterations to cellular and molecular programs with brain aging result in cognitive impairment and susceptibility to neurodegenerative disease. Changes in DNA methylation patterns, an epigenetic modification required for various CNS functions are observed with brain aging and can...

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Bibliographic Details
Main Authors: Niran Hadad, Dustin R. Masser, Laura Blanco-Berdugo, David R. Stanford, Willard M. Freeman
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Epigenetics & Chromatin
Subjects:
DNA methylation
Aging
Epigenetics
Gene regulation
Hippocampus
Online Access:http://link.springer.com/article/10.1186/s13072-019-0306-5

Internet

http://link.springer.com/article/10.1186/s13072-019-0306-5

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