IL-2 expression in activated human memory FOXP3+ cells critically depends on the cellular levels of FOXP3 as well as of four transcription factors of T cell activation

IL-2 expression in activated human memory FOXP3+ cells critically depends on the cellular levels of FOXP3 as well as of four transcription factors of T cell activation

The human CD4+FOXP3+ T cell population is heterogeneous and consists of various subpopulations which remain poorly defined. Anergy and suppression are two main functional characteristics of FOXP3+Treg cells. We used the anergic behavior of FOXP3+Treg cells for a better discrimination and characteriz...

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Bibliographic Details
Main Authors: Hanna eBendfeldt, Manuela eBenary, Tobias eScheel, Kerstin eSteinbrink, Andreas eRadbruch, Ria eBaumgrass
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Immunology
Subjects:
Flow Cytometry
Transcription Factors
T cell
lymphocyte
Cytokine expression
human Treg cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00264/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00264/full

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