Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis

Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis

The dry roots of Polygonum multiflorum (PM), involving both the raw and processed materials, are widely used as the traditional Chinese medicine for treating various diseases in China. Hepatotoxicity has been occasionally reported in patients who consume PM. Unfortunately, no definite criteria are c...

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Bibliographic Details
Main Authors: Lifeng Han, Piao Wang, Yulan Wang, Qianyu Zhao, Fang Zheng, Zhiying Dou, Wenzhi Yang, Limin Hu, Caixiang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
Polygonum multiflorum
metabolomics
hepatotoxicity
L02 cell
UHPLC/Q-Orbitrap-MS
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00329/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00329/full

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