The MOBSTER R package for tumour subclonal deconvolution from bulk DNA whole-genome sequencing data

The MOBSTER R package for tumour subclonal deconvolution from bulk DNA whole-genome sequencing data

Abstract Background The large-scale availability of whole-genome sequencing profiles from bulk DNA sequencing of cancer tissues is fueling the application of evolutionary theory to cancer. From a bulk biopsy, subclonal deconvolution methods are used to determine the composition of cancer subpopulati...

Full description

Bibliographic Details
Main Authors: Giulio Caravagna, Guido Sanguinetti, Trevor A. Graham, Andrea Sottoriva
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Bioinformatics
Subjects:
Tumour subclonal deconvolution
Cancer evolution
Population genetics
Dirichlet mixture model
Whole-genome DNA sequencing
Online Access:http://link.springer.com/article/10.1186/s12859-020-03863-1

Internet

http://link.springer.com/article/10.1186/s12859-020-03863-1

Similar Items