The First Insight Into the Supramolecular System of D,L-α-Difluoromethylornithine: A New Antiviral Perspective

The First Insight Into the Supramolecular System of D,L-α-Difluoromethylornithine: A New Antiviral Perspective

Targeting the polyamine biosynthetic pathway by inhibiting ornithine decarboxylase (ODC) is a powerful approach in the fight against diverse viruses, including SARS-CoV-2. Difluoromethylornithine (DFMO, eflornithine) is the best-known inhibitor of ODC and a broad-spectrum, unique therapeutical agent...

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Bibliographic Details
Main Authors: Joanna Bojarska, Roger New, Paweł Borowiecki, Milan Remko, Martin Breza, Izabela D. Madura, Andrzej Fruziński, Anna Pietrzak, Wojciech M. Wolf
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Chemistry
Subjects:
difluoromethylornithine
DFMO
eflornithine
ornidyl
coronavirus
SARS-CoV-2
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.679776/full

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https://www.frontiersin.org/articles/10.3389/fchem.2021.679776/full

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