Receptor tyrosine kinases play a significant role in human oligodendrocyte inflammation and cell death associated with the Lyme disease bacterium Borrelia burgdorferi

Receptor tyrosine kinases play a significant role in human oligodendrocyte inflammation and cell death associated with the Lyme disease bacterium Borrelia burgdorferi

Abstract Background In previous studies, human oligodendrocytes were demonstrated to undergo apoptosis in the presence of Borrelia burgdorferi under an inflammatory milieu. Subsequently, we determined that the MEK/ERK pathway played a significant role in triggering downstream inflammation as well as...

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Bibliographic Details
Main Authors: Geetha Parthasarathy, Mario T. Philipp
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Journal of Neuroinflammation
Subjects:
B. burgdorferi
Human oligodendrocytes
Inflammation
Receptor tyrosine kinases
Lyme neuroborreliosis
Online Access:http://link.springer.com/article/10.1186/s12974-017-0883-9

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http://link.springer.com/article/10.1186/s12974-017-0883-9

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