Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects

Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects

Phosphodiesterase (PDE) enzymes regulate the levels of cyclic nucleotides, cAMP, and/or cGMP, being attractive therapeutic targets. In order to modulate PDE activity in a selective way, we focused our efforts on the search of allosteric modulators. Based on the crystal structure of the PDE10A GAF-B...

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Bibliographic Details
Main Authors: Ana M. García, José Brea, Alejandro González-García, Concepción Pérez, María Isabel Cadavid, María Isabel Loza, Ana Martinez, Carmen Gil
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Molecules
Subjects:
PDE10 inhibitors
allosteric modulators
cAMP
GAF domain
anti-inflammatory
Online Access:https://www.mdpi.com/1420-3049/22/9/1472

Internet

https://www.mdpi.com/1420-3049/22/9/1472

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