Loss of function of the mouse Sharpin gene results in Peyer's patch regression.

Loss of function of the mouse Sharpin gene results in Peyer's patch regression.

Peyer's patches (PP) are an important component in the immune response against intestinal pathogens. Two independent, spontaneous mutations in the mouse Sharpin gene (Sharpin(cpdm) and Sharpin(cpdm-Dem)) result in the absence of PP and disrupted splenic white pulp in adult mice, although a full...

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Bibliographic Details
Main Authors: Rosemarie Seymour, Bobbi-Jo Shirley, Harm Hogenesch, Leonard D Shultz, John P Sundberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3570409?pdf=render

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http://europepmc.org/articles/PMC3570409?pdf=render

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