Histone deacetylase inhibitor panobinostat induces antitumor activity in epithelioid sarcoma and rhabdoid tumor by growth factor receptor modulation

Histone deacetylase inhibitor panobinostat induces antitumor activity in epithelioid sarcoma and rhabdoid tumor by growth factor receptor modulation

Abstract Background Epithelioid sarcomas and rhabdoid tumors are rare, aggressive malignancies with poor prognosis. Both are characterized by INI1 alterations and deregulation of growth factor receptors albeit their interaction has not been elucidated. Methods In this study, we investigated the acti...

Full description

Bibliographic Details
Main Authors: Anne Catherine Harttrampf, Maria Eugenia Marques da Costa, Aline Renoult, Estelle Daudigeos-Dubus, Birgit Geoerger
Format: Article
Language:English
Published: BMC 2021-07-01
Series:BMC Cancer
Subjects:
Epithelioid sarcoma
Rhabdoid tumor
HDAC inhibition
Epithelial-to mesenchymal transition
Growth factor receptors
Online Access:https://doi.org/10.1186/s12885-021-08579-w

Internet

https://doi.org/10.1186/s12885-021-08579-w

Similar Items