Synergistic combination of two antimicrobial agents closing each other’s mutant selection windows to prevent antimicrobial resistance

Abstract Antimicrobial resistance seriously threatened human health. Combination therapy is generally an effective strategy to fight resistance, while some data on its effects are conflicting. To explore the reasons, the fractional inhibitory concentration indexes (FICIs) of three designed combinati...

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Bibliographic Details
Main Authors: Xuejie Xu, Li Xu, Ganjun Yuan, Yimin Wang, Yunqiu Qu, Meijing Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-25714-z