The melanoma brain metastatic microenvironment: aldolase C partakes in shaping the malignant phenotype of melanoma cells – a case of inter‐tumor heterogeneity

The melanoma brain metastatic microenvironment: aldolase C partakes in shaping the malignant phenotype of melanoma cells – a case of inter‐tumor heterogeneity

Previous studies indicated that microglia cells upregulate the expression of aldolase C (ALDOC) in melanoma cells. The present study using brain‐metastasizing variants from three human melanomas explores the functional role of ALDOC in the formation and maintenance of melanoma brain metastasis (MBM)...

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Bibliographic Details
Main Authors: Sivan Izraely, Shlomit Ben‐Menachem, Orit Sagi‐Assif, Tsipi Meshel, Sapir Malka, Alona Telerman, Matias A. Bustos, Romela Irene Ramos, Metsada Pasmanik‐Chor, Dave S. B. Hoon, Isaac P. Witz
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Molecular Oncology
Subjects:
aldolase C
brain metastasis
melanoma
microglia
tumor microenvironment
Online Access:https://doi.org/10.1002/1878-0261.12872

Internet

https://doi.org/10.1002/1878-0261.12872

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