Conditional knock-out of lipoic acid protein ligase 1 reveals redundancy pathway for lipoic acid metabolism in Plasmodium berghei malaria parasite

Conditional knock-out of lipoic acid protein ligase 1 reveals redundancy pathway for lipoic acid metabolism in Plasmodium berghei malaria parasite

Abstract Background Lipoic acid is a cofactor for α-keto acid dehydrogenase system that is involved in the central energy metabolism. In the apicomplexan parasite, Plasmodium, lipoic acid protein ligase 1 (LplA1) and LplA2 catalyse the ligation of acquired lipoic acid to the dehydrogenase complexes...

Full description

Bibliographic Details
Main Authors: Min Wang, Qiong Wang, Xiang Gao, Zhong Su
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Parasites & Vectors
Subjects:
Plasmodium berghei
Lipoic acid protein ligase
Tetracycline-inducible transcription system
Conditional knockout
Online Access:http://link.springer.com/article/10.1186/s13071-017-2253-y

Internet

http://link.springer.com/article/10.1186/s13071-017-2253-y

Similar Items