The Sequence of Delta24-RGD and TMZ Administration in Malignant Glioma Affects the Role of CD8+T Cell Anti-tumor Activity

The Sequence of Delta24-RGD and TMZ Administration in Malignant Glioma Affects the Role of CD8+T Cell Anti-tumor Activity

The conditionally replicating oncolytic adenovirus Delta24-RGD (Ad) is currently under investigation in clinical trials for glioblastoma, including in combination with temozolomide (TMZ), the standard chemotherapy for this tumor. Previously, we showed that the efficacy of Delta24-RGD in a murine mod...

Full description

Bibliographic Details
Main Authors: Anne Kleijn, Wouter van den Bossche, Erik S. Haefner, Zineb Belcaid, Chantal Burghoorn-Maas, Jenneke J. Kloezeman, Suzan D. Pas, Sieger Leenstra, Reno Debets, Jeroen de Vrij, Clemens M.F. Dirven, Martine L.M. Lamfers
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
glioma
oncolytic virotherapy
adenovirus
immune response
temozolomide
mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770517300050

Internet

http://www.sciencedirect.com/science/article/pii/S2372770517300050

Similar Items