Effect of Storage Humidity on Physical Stability of Spray-Dried Naproxen Amorphous Solid Dispersions with Polyvinylpyrrolidone: Two Fluid Nozzle vs. Three Fluid Nozzle

Effect of Storage Humidity on Physical Stability of Spray-Dried Naproxen Amorphous Solid Dispersions with Polyvinylpyrrolidone: Two Fluid Nozzle vs. Three Fluid Nozzle

In a spray drying operation, a two-fluid nozzle (2FN) with a single channel is commonly used for atomizing the feed solution. However, the less commonly used three-fluid nozzle (3FN) has two separate channels, which allow spray drying of materials in two incompatible solution systems. Although amorp...

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Bibliographic Details
Main Authors: Sonal V. Bhujbal, Yongchao Su, Vaibhav Pathak, Dmitry Y. Zemlyanov, Alex-Anthony Cavallaro, Eric J. Munson, Lynne S. Taylor, Qi (Tony) Zhou
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
amorphous solid dispersions
particle formulation
spray drying
physical stability
three fluid nozzle
Online Access:https://www.mdpi.com/1999-4923/13/7/1074

Internet

https://www.mdpi.com/1999-4923/13/7/1074

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