Inhibition of MHC class I is a virulence factor in herpes simplex virus infection of mice.
Herpes simplex virus (HSV) has a number of genes devoted to immune evasion. One such gene, ICP47, binds to the transporter associated with antigen presentation (TAP) 1/2 thereby preventing transport of viral peptides into the endoplasmic reticulum, loading of peptides onto nascent major histocompati...
| Format: | Article |
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| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-09-01
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| Series: | PLoS Pathogens |
| Online Access: | http://dx.doi.org/10.1371/journal.ppat.0010007 |