NKTR-358: A novel regulatory T-cell stimulator that selectively stimulates expansion and suppressive function of regulatory T cells for the treatment of autoimmune and inflammatory diseases

NKTR-358: A novel regulatory T-cell stimulator that selectively stimulates expansion and suppressive function of regulatory T cells for the treatment of autoimmune and inflammatory diseases

Impaired interleukin-2 (IL-2) production and regulatory T-cell dysfunction have been implicated as immunological mechanisms central to the pathogenesis of multiple autoimmune and inflammatory diseases. NKTR-358, a novel regulatory T-cell stimulator, is an investigational therapeutic that selectively...

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Bibliographic Details
Main Authors: Neha Dixit, Christie Fanton, John L. Langowski, Yolanda Kirksey, Peter Kirk, Thomas Chang, Janet Cetz, Vidula Dixit, Grace Kim, Peiwen Kuo, Mekhala Maiti, Yinyan Tang, Laurie A. VanderVeen, Ping Zhang, Myong Lee, Jerome Ritz, Yusuke Kamihara, Chunmei Ji, Werner Rubas, Theresa D. Sweeney, Stephen K. Doberstein, Jonathan Zalevsky
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Translational Autoimmunity
Subjects:
Interleukin-2
IL-2 receptor
Systemic lupus erythematosus
Regulatory T cells
Autoimmune disease
Therapeutic
Online Access:http://www.sciencedirect.com/science/article/pii/S258990902100023X

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http://www.sciencedirect.com/science/article/pii/S258990902100023X

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