Quantifying Breast Cancer-Driven Fiber Alignment and Collagen Deposition in Primary Human Breast Tissue

Quantifying Breast Cancer-Driven Fiber Alignment and Collagen Deposition in Primary Human Breast Tissue

Solid tumor progression is significantly influenced by interactions between cancer cells and the surrounding extracellular matrix (ECM). Specifically, the cancer cell-driven changes to ECM fiber alignment and collagen deposition impact tumor growth and metastasis. Current methods of quantifying thes...

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Bibliographic Details
Main Authors: Rakesh Gurrala, C. Ethan Byrne, Loren M. Brown, Rafael Felix P. Tiongco, Margarite D. Matossian, Jonathan J. Savoie, Bridgette M. Collins-Burow, Matthew E. Burow, Elizabeth C. Martin, Frank H. Lau
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
breast cancer
extracellular matrix
fiber alignment
collagen content
second harmonic generation
scanning electron microscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.618448/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.618448/full

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