X-Linked RNA-Binding Motif Protein Modulates HIV-1 Infection of CD4+ T Cells by Maintaining the Trimethylation of Histone H3 Lysine 9 at the Downstream Region of the 5′ Long Terminal Repeat of HIV Proviral DNA

X-Linked RNA-Binding Motif Protein Modulates HIV-1 Infection of CD4+ T Cells by Maintaining the Trimethylation of Histone H3 Lysine 9 at the Downstream Region of the 5′ Long Terminal Repeat of HIV Proviral DNA

HIV-1 latency featuring silence of transcription from HIV-1 proviral DNA represents a major obstacle for HIV-1 eradication. Reversible repression of HIV-1 5′-LTR-mediated transcription represents the main mechanism for HIV-1 to maintain latency. The 5′-LTR-driven HIV gene transcription can be modula...

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Bibliographic Details
Main Authors: Li Ma, Qing-An Jiang, Li Sun, Xianguang Yang, Hai Huang, Xia Jin, Chiyu Zhang, Jian-Hua Wang
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
hiv-1
rbmx
transcription
h3k9me3
Online Access:https://doi.org/10.1128/mBio.03424-19

Internet

https://doi.org/10.1128/mBio.03424-19

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